Virginia is dismayed to hear that her parents marriage is on the rocks; Bill learns that Louise has fallen off the wagon; Libby and Bram get stuck in a traffic jam.
- Michael Sheen as William Masters
- Lizzy Caplan as Virginia Johnson
- Caitlin FitzGerald as Libby Masters
- Annaleigh Ashford as Betty DiMello
"Night and Day" received very positive reviews.